Influence of surgical resection extent on prognosis of high-risk gastrointestinal stromal tumors
10.3969/j.issn.1671-8348.2014.25.009
- VernacularTitle:手术切除程度对高危胃肠间质瘤预后的影响
- Author:
Wei LI
;
Ling ZHOU
;
Min LI
- Publication Type:Journal Article
- Keywords:
gastrointestinal stromal tumors;
high risk;
surgery
- From:
Chongqing Medicine
2014;(25):3290-3292
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics,surgical resection extent and prognosis influencing factors of pri-mary high-risk gastrointestinal stromal tumors(GIST).Methods The clinicopathological and follow-up data of 48 patients with pri-mary resectable high-risk GIST in this hospital from January 2005 to January 2013 were retrospectively analyzed.The influence of three kinds of different surgical resection methods on the prognosis of GIST was analyzed.Results 34 cases were treated by R0 re-section(70.83%),6 cases by R1 resection(11.50%)and 8 cases by R2 resection(16.67%).All cases were given the postoperative adjuvant therapy of imatinib mesylate.The average medication time was(26.5±13.6)months.The occurrence rate of adverse drug reactions was 100%,and the main symptoms were swelling and leukopenia.The 5-year survival rates in 3 kinds of resection modes were 97.06%,66.67% and 25.00% respectively.The univariate and multivariate prognostic analysis showed that the surgical re-section extent and the tumor rupture were the independent prognostic factors in the high-risk GIST patients.Conclusion The intact operative resection and preventing the tumor rupture are the keys to increase the postoperative survival rate of GIST patients.
