Clinical Investigation of Biodegradable Polymer Sirolimns-eluting Stents in Treating the Patients With Diffuse Long Coronary Lesions
10.3969/j.issn.1000-3614.2014.09.004
- VernacularTitle:可降解聚合物涂层雷帕霉素洗脱支架在治疗冠状动脉弥漫性长病变中的临床研究
- Author:
Xiaotao LI
;
Lefeng WANG
;
Xinchun YANG
;
Hongshi WANG
;
Hao SUN
;
Jinghong GAO
;
Kun XIA
;
Yongli XUE
;
Jing XUE
;
Chao XU
- Publication Type:Journal Article
- Keywords:
Coronary artery disease;
Percutaneous coronary intervention;
Biodegradable polymer drug-eluting stent
- From:
Chinese Circulation Journal
2014;(9):670-673
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the efficacy and safety of overlapping biodegradable polymer sirolimus-eluting stents (EXCEL) in treating the patients with diffuse long coronary lesions (total stent length for per lesion>60 mm).
Methods: A total of 71 patients with diffuse long coronary lesions with overlapped EXcellstents implantation in our hospital from 2010-08 to 2012-05 were retrospectively studied. The average age of patients was (62.85 ± 10.26) years and 74.56%with male gender. The clinical endpoints were the major adverse cardiac events (MACE) at in-hospital time and at 2-year follow-up period.
Results: The average target lesion was implanted (2.61 ± 0.52) stents, the mean stent diameter was (3.21 ± 0.35) mm and the length was (73.34 ± 13.11) mm. The in-hospital MACE rate was 4.23%, the 2-year target vessel revascularization and MACE rates were 9.86%and 18.31%respectively. Cox regression analysis indicated that smoking (HR 12.102, 95%CI 1.460-100.309, P=0.021), previous history of MI (HR 11.948, 95%CI 1.144-124.726, P=0.038) and previous history of PCI (HR 0.097, 95%CI 0.010-0.990, P=0.049) were the independent risk factors of out of hospital MACE occurrence.
Conclusion: EXcellstent implantation was safe and effective for treating the patients with diffuse long coronary lesions, the long term follow-up study revealed that there was the increased risk for MACE and target vessel revascularization.
