Assessment of Clinical Values on N-terminal Pro-brain Natriuretic Peptide in Elder Patients With Heart Failure
10.3969/j.issn.1000-3614.2014.09.011
- VernacularTitle:N末端B型利钠肽原对老年心力衰竭临床应用价值的研究
- Author:
Guopeng HUANG
;
Su AN
- Publication Type:Journal Article
- Keywords:
Diastolic heart failure;
Systolic heart failure;
N-terminal pro-brain natriuretic peptide;
Troponin;
Left ventricular ejection fraction;
Left ventricular end diastolic diameter
- From:
Chinese Circulation Journal
2014;(9):698-701
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To assess the clinical value of serum N-terminal pro-brain natriuretic peptide (NT-ProBNP) values in elder patients with heart failure (HF).
Methods: According to NYHA classiifcation, a total of 384 HF patients were divided into 4 groups as NYHA I group, n=35, NYHA II group, n=89, NYHA III group, n=163, NYHA IV group, n=97;and Control group, n=69 normal subjects. The NT-ProBNP and troponin (cTn1) levels were examined in systolic HF and diastolic HF patients, the relationship between NT-ProBNP and left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD) were studied.
Results: For NT-ProBNP levels, Control group and NYHA I group were similar, P>0.05; while it was different among each HF groups, P<0.05. For cTn1 levels, Control group, NYHA I group and NYHA II group were similar, P>0.05;while NYHA III group and NYHA IV group were different from other groups, P<0.05. The patients with systolic HF had the higher NT-ProBNP and LVEDD, the patients with diastolic HF had the higher LVEF. In elder HF patients, NT-ProBNP level was negatively related to LVEF (r=-0.687, P<0.05) and positively correlated to LVEDD (r=0.735, P<0.05).
Conclusion: NT-ProBNP may better reflect the cardiac structural and functional changes in HF patients, it is important for HF early diagnosis and prognosis in clinical practice.
