Study on Serum Pharmacochemistry of Ke-Luo-Xin Capsule
10.11842/wst.2014.08.017
- VernacularTitle:渴络欣胶囊的血清药物化学研究
- Author:
Jianming WU
;
Zhirong ZHANG
;
Hongcheng ZHANG
;
Xiao KE
;
Xiaofeng HAO
;
Xiaoping GAO
- Publication Type:Journal Article
- Keywords:
Ke-Luo-Xin capsule;
aloeemodin;
RP-HPLC;
serum pharmacochemistry
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2014;(8):1784-1788
- CountryChina
- Language:Chinese
-
Abstract:
This article was aimed to study the main effective substances and characteristics of Ke-Luo-Xin (KLX) capsule. HPLC-DAD system was applied in the establishment of HPLC finger prints of serum of rats after taking KLX capsule. And then, serum samples taken KLX capsule, blank blood serum, and single crude drugs were com-pared. Constituents absorbed into the serum were determined by HPLC-DAD system. The results showed that meth-ods for serum HPLC fingerprinting had good precision, reproducibility and stability. A total of 13 constituents migrat-ing to the blood were detected, of which 9 were prototype constituents, 4 were metabolites. Prototype constituents in-cluded aloeemodin and chrysophanic acid. It was concluded that 13 constituents migrating to the blood may be the main effective substances of KLX capsule.
