A Systematic Review of Randomized Controlled Trials for Clinical Efficacy and OS on Xi-Pa-Yi Mouth Rinse for Simple Gingivitis

Hongyan Sun; Ankun LV

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A Systematic Review of Randomized Controlled Trials for Clinical Efficacy and OS on Xi-Pa-Yi Mouth Rinse for Simple Gingivitis

VernacularTitle:西帕依固龈液治疗单纯性牙龈炎临床疗效及口臭值的系统评价
Author: Hongyan SUN ; Ankun LV
Publication Type:Journal Article
Keywords: Xi-Pa-Y i Mouth Rinse; simple gingivitis; systematic review; clinical efficacy; halitosis value
From: World Science and Technology-Modernization of Traditional Chinese Medicine 2014;(8):1850-1854
CountryChina
Language:Chinese
Abstract: This study was aimed to evaluate the clinical efficacy of Xi-Pa-Y i (XPY) Mouth Rinse in the treatment of simple gingivitis and improved value for halitosis. Related literatures were systematically searched in the China Na-tional Knowledge Infrastructure (CNKI, 1979-2012), Weipu Database for Chinese Technical Periodicals (1989-2013), PubMed and Cochrane Library. The methodological quality of included trials was assessed based on the Jadad scale. And the available data were analyzed with RevMan software (version 5.2.0). The results showed that a total of 4 stud-ies involving 360 participants satisfied the minimum criteria for meta-analysis. The evidences showed that the XPY Mouth Rinse was compared with saline or western medicine for treatment of the OS of simple gingivitis WMD (95%confidence interval) were -0.48 (-0.81, -0.16), 0.04 (-0.15, 0.22), respectively; the XPY Mouth Rinse was com-pared with saline or western medicine for treatment of simple gingivitis clinical efficacy's RR (95% confidence inter-val) were 1.67 (1.29, 2.15), 1.22 (0.35, 4.20), respectively. It was concluded that the current clinical evidence showed that the effectiveness of XPY Mouth Rinse in the treatment of simple gingivitis was higher than the saline. It had similar effects with western medicine, which can reduce the OS, and with no significant side effects and easy to take. However, due to the low quality studies and small sample amount, it is still need to be confirmed by the high-quality, multi-center, large sample, randomized, double-blind clinical controlled trials.