Screening Technology for Traditional Chinese Medicine New Drug and Practice
10.11842/wst.2014.08.003
- VernacularTitle:中药新药筛选新技术及实践
- Author:
Yaosheng TU
;
Dongmei SUN
;
Yuxing CHEN
;
Xiaohui ZENG
;
Dane HUANG
;
Dengping TAN
- Publication Type:Journal Article
- Keywords:
TCM new drug;
screening;
new technology;
practice
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2014;(8):1696-1702
- CountryChina
- Language:Chinese
-
Abstract:
This article focused on summarization of the available new screening technology for traditional Chinese medicine (TCM) new drug, including high throughput screening (HTS), biological chip, molecular biological chro-matography, high content screening (HCS), network pharmacology, proteomics, and computer-aided drug design (CADD). And in this review, one example that we applied CADD technology (such as molecular docking, pharma-cophore and molecular similarity) in lipid-lowering TCM new drug development was given. Based on the mechanism of lipid metabolism, CADD technology provided a good method on the prescription optimization and mechanism study. In addition, TCM new drug development proposal which displayed in this paper may provide a useful strategy for screening of TCM new drug.
