Changes of IL-8 and ICAM-1 in early stage of cerebral white matter damage and their correlations with prognosis in premature infants
10.3969/j.issn.1000-3606.2014.09.006
- VernacularTitle:白细胞介素-8和细胞间黏附分子-1在早产儿脑白质损伤早期变化及其与预后的关系
- Author:
Yang DUAN
;
Fuqiang SUN
;
Yueqin LI
- Publication Type:Journal Article
- Keywords:
cerebral white matter damage;
interleukin-8;
intercellular adhesion molecule-1;
premature infant
- From:
Journal of Clinical Pediatrics
2014;(9):821-824
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the IL-8 and ICAM-1 in premature infants with cerebral white matter damage (CWMD) and their correlations with prognosis. Methods One hundred and two cases of CWMD were selected from March 2009 to June 2012 as experimental group and 42 cases of normal preterm children were selected as control group. Serum IL-8 and ICAM-1 levels were measured during 48-72 h after birth. Motor development index (psychomotor developmental index, PDI) and mental development index (mental development index, MDI) were evaluated by Bayley scale. The correlations of IL-8 and ICAM-1 levels with prognosis were analyzed. Results Serum IL-8 and ICAM-1 levels in the experimental group were signiifcantly higher than those in the control group (P<0.05). MDI and PDI scores in the experimental group were signiifcantly lower than those in the control group (P<0.05). There were negative correlations of serum IL-8 and ICAM-1 levels with MDI (r=-0.64, P<0.05;r=-0.66, P<0.05)+and PDI (r=-0.70, P<0.05;r=-0.71, P<0.05). Conclusions Serum IL-8 and ICAM-1 levels in infants with CWMD are signiifcantly increased, and are negatively correlated with MDI and PDI scores.
