Establishment of mannitol-induced infusion phlebitis animal model
10.3760/cma.j.issn.1672-7088.2014.23.003
- VernacularTitle:甘露醇致输液性静脉炎动物模型的建立
- Author:
Linsheng SHEN
;
Ping WANG
;
Dengke XIAO
;
Ruyan ZHANG
;
Yuanyuan MIAO
;
Yulu GUO
- Publication Type:Journal Article
- Keywords:
Infusion phlebitis;
Mannitol;
Animal model;
Rabbit
- From:
Chinese Journal of Practical Nursing
2014;30(23):9-11
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the reasonable experimental parameters on establishment of rabbit model of infusion phlebitis induced by mannitol.Methods New Zealand rabbits were injected with 20％ mannitol,then pathological lesion of rabbit auricular vein induced by different infusion velocity,different sampling time and sites were observed under microscope with vascular injury,inflammatory cell infiltration,frequency of thrombokinesis as indexes.Results The three indexes were the highest and the most obvious characteristics of infusion phlebitis were noted at the following experimental conditions:5.0 ml/min (infusion velocity),sampling time at 24h after administration and sampling site at 1cm region in front of the catheter tip.Conclusions Rabbit model of infusion phlebitis induced by mannitol can be set up more stable by using these parameters.
