Progress of microRNAs in pathogenesis of sepsis
10.3760/cma.j.issn.2095-428X.2014.18.015
- VernacularTitle:微小RNA在脓毒症发病机制的作用研究进展
- Author:
Xin LYU
;
Yucai ZHANG
- Publication Type:Journal Article
- Keywords:
MicroRNA;
Sepsis;
Immunomodulation
- From:
Chinese Journal of Applied Clinical Pediatrics
2014;29(18):1416-1418
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs are small,single-stranded and non-coding RNAs.MicroRNAs modulates gene expression by binding themselves to complementary sites of target genes.It had been discovered that micmRNAs modulate sepsis in multiple levels.Through targeting Ca2+/calmodulin-dependent protein kinase Ⅱ,miR-152 and miR-148 impair innate response and antigen presentation,and also suppress proliferation of antigen specific CD4 + T cells; miR-29 family regulate cellular immunity through setting the threshold in thymic involution; MicroRNA-17-92 plays a causative role in B cell lineage; miR-146 and miR-155 down-regulate proinflammatory cytokines through suppressing components of pattern recognition receptors,while miR-132 through acetylcholinesterase degeneration.miR-124 degenerates mRNA of glucocorticoid receptorαand results in glucocorticoid resistant in treatment of sepsis.Immune regulation of microRNAs in sepsis is briefly described in this paper.
