C-Kit-Negative Gastrointestinal Stromal Tumor in the Stomach.
10.5230/jgc.2015.15.4.290
- Author:
Ho Seok SEO
1
;
Ji Yeon HYEON
;
Ok Ran SHIN
;
Han Hong LEE
Author Information
1. Division of Gastrointestinal Surgery, Department of Surgery, The Catholic University of Korea, Seoul, Korea. painkiller9@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
C-kit protein;
DOG1 protein;
Gastrointestinal stromal tumors
- MeSH:
Diagnosis;
Gastrointestinal Stromal Tumors*;
Humans;
Proto-Oncogene Proteins c-kit;
Stomach*;
Imatinib Mesylate
- From:Journal of Gastric Cancer
2015;15(4):290-294
- CountryRepublic of Korea
- Language:English
-
Abstract:
C-kit-negative gastrointestinal stromal tumors (GISTs) are uncommon, and there have been few reports about the diagnosis and treatment of c-kit-negative GISTs in the stomach. We report the case of a patient who was diagnosed with a huge and atypical GIST in the stomach. The GIST was completely resected and finally diagnosed as c-kit-negative GIST based on immunohistochemical staining of tumor cells, which were negative for CD117 and CD34 and positive for Discovered on GIST-1 (DOG1). C-kit-negative GISTs could be treated by complete resection and/or imatinib, which is the same treatment for c-kit-positive GISTs.
