Treatment of Henoch-Sch(o)nlein purpura nephritis in children
10.3760/cma.j.issn.2095-428X.2014.17.003
- VernacularTitle:儿童紫癜性肾炎的综合治疗
- Author:
Jianhua MAO
;
Li WU
- Publication Type:Journal Article
- Keywords:
Child;
Henoch-sch(o)nlein purpura nephritis;
Combined therapy;
Immunosuppressive agents
- From:
Chinese Journal of Applied Clinical Pediatrics
2014;29(17):1287-1290
- CountryChina
- Language:Chinese
-
Abstract:
Henoch-Sch(o)nlein purpura(HSP) is one of the most common vasculitides in children with many manifestations including skin purpura,arthritis,abdominal pain and renal involvement.The renal involvement(Henoch-Sch(o)nlein purpura nephritis,HSPN) is the principal cause of morbidity and major risk factor for prognosis in HSP.The paper reviewed the updated treatment strategy for HSPN.Accordingly,steroids,cyclophosphamide,mycophenolate mofetil,mizoribine,cyclosporine,triptolide,angiotensin converting enzyme inhibitors (ACEI) / angiotensin receptor blockers(ARB),plasma apheresis and tonsillectomy are possible indicator for the further therapy of HSPN.Furthermore,prospective randomized controlled treatment studies on children with severe HSPN would be needed.
