The zebrafish as a model organism for the research of neonatal hypoxia brain injury
10.3760/cma.j.issn.2095-428X.2014.14.015
- VernacularTitle:模式生物斑马鱼在新生儿缺氧性脑损伤研究中的应用
- Author:
Dan ZHAO
;
Yan CHENG
;
Yanchen CHEN
;
Bin WANG
- Publication Type:Journal Article
- Keywords:
Zebrafish;
Hypoxia;
Hypoxia brain injury;
Animal model;
Drug screening
- From:
Chinese Journal of Applied Clinical Pediatrics
2014;29(14):1100-1104
- CountryChina
- Language:Chinese
-
Abstract:
Many factors,especially perinatal asphyxia,can lead to varying degrees of hypoxia brain injury in fetus or newborns within perinatal period.So far,the mechanisms of neonatal cerebral damage caused by hypoxia during the perinatal period have not been clearly demonstrated,and there have no effective drugs or therapeutic methods to improve hypoxia-induced cerebral damage.This review focuses on the recent progress of zebrafish as a model organism of using in research of hypoxia brain injury,including the anatomic and behavior basis,model making,research strategies and the advantages of neurotrophic drug screening.The application of zebrish in the research of neonatal hypoxic brain injury is promising,and may provide a new tool as research in finding out the therapy strategies of hypoxic-ischemic encephalopathy.
