Changes in amino-terminal pro-brain natriuretic peptide plasma level in children with dilated cardiomyopathy before and after treatment
10.3760/cma.j.issn.2095-428X.2014.13.015
- VernacularTitle:扩张型心肌病患儿治疗前后氨基末端脑钠尿肽原的变化及意义
- Author:
Yefeng WANG
;
Zhi CHEN
;
Min ZENG
;
Xun WANG
- Publication Type:Journal Article
- Keywords:
N-terminal pro-brain natriuretic peptide;
Dilated cardiomyopathy;
Heart failure
- From:
Chinese Journal of Applied Clinical Pediatrics
2014;29(13):1010-1013
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the plasma level of amino-terminal pro-brain natriuretic peptide(NT-proBNP) before and after treatment in children with dilated cardiomyopathy (DCM) and explore the relationship between NTproBNP and heart functional classes.To evaluate the significance of dynamic change in NT-proBNP level in children with dilated cardiomyopathy.Methods The study comprised 49 children with DCM from Aug.2011 to Sep.2013 in Hunan Children's Hospital.NT-proBNP levels were measured before and after treatment.All the patients were evaluated under the modified Ross Heart Association functional class and echocardiographic determination of left ventricular ejection fraction(LVEF) and fractional shortening(SF).The patients were divided into improvement group(38 cases) and the non-improvement group(11 cases) according to cardiac function after treatment.Results The plasma level of NTproBNP was positively correlated with Ross heart failure classification (r =0.756,P ＜ 0.01),and much better than LVEF and SF.To identify mild heart failure,the cut-off value of 329 ng/L was 93.8％ sensitive and 90.9％ specific.To identify moderate heart failure,the cut-off value of 2 833 ng/L was 95.6％ sensitive and 92.9％ specific.To identify severe heart failure,the cut-off value of 12 125 ng/L was 80.6％ sensitive and 84.8％ specific.There was significant difference in the improvement group before and after treatment(t =2.357,P ＜ 0.05).In non-improvement group there was no significant difference (t =0.132,P =0.778) before and after treatment.Conclusions There is significant correlation between the plasma level of NT-proBNP and heart failure severity.The dynamic changes in NT-proBNP levels before and after treatment can help us to determine the effect of treatment and prognosis.
