Use of glucocorticoid in severe hand-foot-mouth disease and the therapeutic effects of different dose of glucocorticoid in Henan and Sichuan Province
10.3760/cma.j.issn.2095-428X.2014.18.005
- VernacularTitle:糖皮质激素在河南、四川两省重症手足口病中的应用现状及不同剂量激素疗效比较
- Author:
Xiangzhi XU
;
Yan JIN
;
Jing ZHANG
;
Suyun QIAN
- Publication Type:Journal Article
- Keywords:
Severe hand-foot-mouth disease;
Enterovirus 71;
Glucocorticoid;
Treatment
- From:
Chinese Journal of Applied Clinical Pediatrics
2014;29(18):1377-1380
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the use of glucocorticoid in severe hand-foot-mouth disease in Henan and Sichuan Province and to compare the therapeutic effects of different dose of glucocorticoid.Methods In this multicenter retrospective study,320 cases of severe hand-foot-mouth disease,which were randomly sampled from Jan.to May 2011 in Henan and Sichuan Province were collected.The use of intravenous glucocorticoid was calculated.Accor-ding to the dose of corticosteroids which had been used,these cases were divided into 3 groups:the non-corticosteroids group,the low-dose group and the high-dose group.The cure rate,febrile duration,nervous system involvement duration,time of staying in hospital,vital signs and serum glucose in 3 groups were compared.Results Patients who used intravenous glucocorticoid accounted for 90.9％ (291/320 cases),and only 29 patients had not used (9.1％).The cure rate among 3 groups were not significantly different(P ＞0.05).In the low-dose group and the high-dose group,the nervous system involvement duration,the febrile duration and time of staying in hospital were longer than those in the non-corticosteroids group (all P ＜ 0.05).Comparing the blood pressure among 3 groups on the first day and the third day of hospitalization,the diastolic blood pressure in the high-dose group was much higher than that in other 2 groups on the third day of hospitalization(all P ＜ 0.05).Conclusions Glucocorticoid is generally used in severe hand-foot-mouth disease in Henan and Sichuan Province.The high-dose glucocorticoid is more often used in the situation that fever,nervous system involvement are not relieved.Glucocorticoid can never improve the cure rate in patients with severe hand-foot-mouth disease or shorten the course,relieve clinical symptoms.The therapeutic effects of glucocorticoid in severe hand-footmouth disease are not confirmed.The therapy of high-dose glucocorticoid may increase medicinal side effects.
