Primary observation of insulin detemir therapy in children and adolescents with type 1 diabetes mellitus
10.3760/cma.j.issn.2095-428X.2014.15.016
- VernacularTitle:地特胰岛素治疗儿童和青少年1型糖尿病的疗效观察
- Author:
Ping YANG
;
Yi WEI
;
Yanxia CHEN
- Publication Type:Journal Article
- Keywords:
Insulin detemir;
Neutral protamine hagedorn;
Type 1 diabetes mellitus;
Child;
Adolescent
- From:
Chinese Journal of Applied Clinical Pediatrics
2014;29(15):1180-1182
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical effect by using insulin detemir therapy in children and adolescents with type 1 diabetes mellitus(T1DM).Methods Thirty children and adolescents with T1DM were divided into 2 groups to receive Humulin R and Determir(observation group,n =15) or Humulin R and neutral protamine hagedorn (NPH) (control group,n =15)insulin therapy.Daily insulin dose,glycemic variability,incidence of non-severe and severe hypoglycemia events after the institution of insulin therapy were collected.Results The daily doses of insulin were (1.16 ± 0.30) U/kg in the observation group and(1.21 ± 0.35) U/kg in the control group,respectively.There was no clinically important change between 2 groups(t =0.526,P ＞ 0.05).Within-subject variation in fasting plasma glucose was significantly lower in observation group(29％)than that in control group(65％) (t =5.296,P ＜0.01).One case of severe hypoglycemia event occurred in the observation group,but 5 cases occurred in the control group(t =4.863,P ＜ 0.0l).Two cases of nocturnal hypoglycaemia(22:00-7:00) events occurred in the observation group,7 cases occurred in the control group(t =4.506,P ＜ 0.01).Conclusions Institution of insulin detemir therapy is associated with low within-subject variation in fasting plasma glucose and decreased rates of severe and nocturnal hypoglycemia while dose of insulin did not increase.This makes insulin detemir a valuable new tool for the treatment of children and adolescents with T1 DM.
