Pathophysiology and treatment of persistent pulmonary hypertension of newborn infants
10.3760/cma.j.issn.2095-428X.2014.14.001
- VernacularTitle:新生儿持续肺动脉高压病理机制及治疗进展
- Author:
Xiaohui CHEN
- Publication Type:Journal Article
- Keywords:
Persistent pulmonary hypertension of newborn;
Pathophysiology;
Treatment
- From:
Chinese Journal of Applied Clinical Pediatrics
2014;29(14):1041-1043
- CountryChina
- Language:Chinese
-
Abstract:
Persistent pulmonary hvpertension of newborn(PPHN) is a life-threatening condition which occurs at a rate of 2/1 000-6/1 000.The etiology of PPHN is still unknown and its treatment remains a major challenge for neonatologist.Impaired pulmonary artery relaxation,reduced blood vessel density and pulmonary vascular remodeling are the main pathological changes in PPHN.The general managements include mechanical ventilation,sedation,surfactant and hemodynamic support.Inhaled nitric oxide is the main vasorelaxant used in the treatment of PPHN.Several other vasorelaxants have been studied such as phosphodiesterase inhibitors,prostacyclin,endothelin-1 inhibitors.Even with the introduction of several new therapeutic modalities there has been no significant change in survival rate.
