Current research status of miRNA-targeted agents for pancreatic cancer
10.3760/cma.j.issn.1673-4203.2014.09.013
- VernacularTitle:胰腺癌miRNA靶向药物研究现状
- Author:
Hua HUANG
;
Taiping ZHANG
;
Yupei ZHAO
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms;
MicroRNAs;
Molecular targeted therapy;
Chemoresistance;
Drug delivery system
- From:
International Journal of Surgery
2014;41(9):625-629
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatic cancer is one of the most aggressive malignancies in the world.Little progress has been made on the treatment of advanced pancreatic cancer in the past 20 years.miRNAs perform a regulatory role in the determination of the final phenotype of cancer cells,including carcinogenesis,metastatic potential,and chemosensitivity.These features of miRNAs have turned them into one of the most popular and promising fields of scientific and clinical research.Issues such as miRNA toxicity to non-target tissues or cells and lack of proper delivery systems for human pancreatic cancer will be the challenges for the field to overcome.
