Roles of NF-κB signaling pathway in regulatory network of pancreatic cancer metastasis
10.3760/cma.j.issn.1673-4203.2014.09.012
- VernacularTitle:NF-κB信号通路在胰腺癌转移调控中的作用机制
- Author:
Yongxing DU
;
Lei YOU
;
Xiaoxia REN
;
Ziwen LIU
;
Yupei ZHAO
- Publication Type:Journal Article
- Keywords:
NF-kappa B;
Pancreatic neoplasms;
Neoplasm metastasis;
Molecular targeted therapy
- From:
International Journal of Surgery
2014;41(9):622-625
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatic cancer is one of the most malignant tumors with a high mortality rate attributed to its widespread metastasis.A number of cellular signal transduction pathways involved in multiple genes play an important role in regulating this complex metastatic cascade of pancreatic cancer.NF-kappa B is one of the crucial signaling pathways.Studies has indicated that NF-kappa B could modulate a series of biological events relevant to tumor progress by controlling multiple targeted genes expression,such as cell proliferation,anti-apoptosis,angiogenesis,epithelial-mesenchymal transition,inflammation,stress response,etc.Furthermore,it can also up-regulate Hedgehog and MMPs signaling pathways.To help us better understand the potential mechanism and identify more sensitive tumor markers and selective targets,this review will underline the significant roles of NF-kappa B signaling pathway in regulatory network of pancreatic cancer metastasis.
