Clinical analysis of 125I radioactive seeds implantation treatment in 26 cases of advanced pancreatic cancer

VernacularTitle:125I放射性粒子植入治疗晚期胰腺癌26例临床分析
Author: Conghui YU ; Junbo YAO ; Ronghua YANG ; Hongfeng NIE ; Peng ZHANG
Publication Type:Journal Article
Keywords: Iodine-125 seeds; Implantation; Carcinoma; Pancreatic neoplasms; Surgical procedures,operative
From: International Journal of Surgery 2014;41(9):614-617
CountryChina
Language:Chinese
Abstract: Objective To investigate the effect of iodine-125 seed implantation in the treatment of unresectable pancreatic carcinoma.Methods A total of 26 pancreatic carcinoma patients were retrospectively analyzed.Patients undergoing palliative operation in combination with iodine-125 seed implantation.jundice recovery,objective tumor response,pain relieved,clinical benefit response,median survival time and complication were investigated.Results Half of cases with jundice has reduced and totally normal in 3 weeks.Abdominal pain was relieved in 94.7％ patients,average recovery duration was (5.0 ± 1.5) d.18 cases had gastroenterol function disorder (69.2％),gastroparesis in six cases (23％) and average recover time was (16 ± 5.1) d.24 of 26 cases were follow up study,median survival time was (12 ± 5.1) months,objective tumor response was smaller than preoperation in 9,no change in 10 and 5 cases became larger than before.Conclusions Palliative operation in combination with iodine-125 seed implantation is safe and effective in the treatment of unresectable pancreatic carcinoma.