Diagnostic value of serum anti-mutated citrullinated vimentin antibodies in patients with rheumatoid arthritis: a Meta-analysis
10.3760/cma.j.issn.1009-9158.2014.08.011
- VernacularTitle:抗突变型瓜氨酸波形蛋白抗体检测对类风湿关节炎诊断的Meta分析
- Author:
Haixi YAN
;
Linling CAI
;
Gaobing JIN
;
Jun LI
- Publication Type:Journal Article
- Keywords:
Arthritis,rheumatoid;
Autoantibodies;
Vimentin;
Meta-analysis
- From:
Chinese Journal of Laboratory Medicine
2014;37(8):603-607
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the diagnostic value of anti-mutated citrullinated vimentin (MCV)antibody for rheumatoid arthritis (RA).Methods Meta analysis.The databases,including PubMed,The Excerpta Medica Database (Embase) and China National Knowledge Infrastructure (CNKI),from January 1990 to January 2013,were employed to search for the studies related to diagnostic value of anti-MCV for RA.The software Meta-Disc1.4 was used to perform Meta-analysis,investigate the sources of heterogeneity and draw the summary receiver operating characteristic (SROC) curve.The Begg's test was applied to evaluate the publication bias by use of Stata1 1 software.Results A total of 27 studies were included.Pooled sensitivity was 0.74[95％ confidence interval (CI) 0.73 to 0.76] and pooled specificity was 0.83 [95％ CI (0.82 to 0.85)].The area under the summary receiver operating characteristic curves was 0.896.Twenty-three literatures which detected both anti-MCV antibody and anti-cyclic citrullinated peptide(antikCCP) antibody show that:the area under curre of anti-MCV antibody and anti-CCP antibody were 0.887 and 0.924 respectively,but there was no significant difference (Z =1.525,P =0.064).Conclusions Results of the meta-analysis demonstrated that the MCV antibody may be a useful parameter in diagnosing RA as it shows high sensitivity and specificity.But there was no statistical difference between the results of anti-MCV antibody and anti-CCP antibody for the RA diagnosis.
