The express of the cytokines KL-6 、FGF-10 、MMP-9 in the spontaneous pneumothorax patients with bulla and its significance
10.3760/cma.j.issn.1001-4497.2014.07.005
- VernacularTitle:细胞因子KL-6、FGF-10、MMP-9在自发性气胸患者肺大疱中的表达及意义
- Author:
Jinxin CAO
;
Jinbai MIAO
;
Hui LI
- Publication Type:Journal Article
- Keywords:
Pneumothorax;
Bulla;
Fibroblast growth factor 10;
Matrix metalloproteinase 9;
KL-6
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2014;30(7):400-403
- CountryChina
- Language:Chinese
-
Abstract:
Objective Spontaneous pneumothorax occurred mainly because of bulla rupture and its formation process and pathogenesis were unknown,the study was to detect the express level of the cytokines KL-6,FGF-10 and MMP-9 in the spontaneous pneumothorax patients with bulla and researched its significance.Methods Selected 24 cases of bulla resection for spontaneous pneumothorax patients,the immunohistochemical staining techniques and enzyme-linked immunosorbent assay (ELISA) was taken to detect the expression level of KL-6,FGF-10 and MMP-9 of the bulla site and the bulla adjacent site.Results Immunohistochemical results showed that the staining intensity of the KL-6 and FGF-10 in groups of bulla site was higher than those in groups of bulla adjacent site while there was no significant difference of MMP-9 in the two groups.ELISA results showed that the expression levels of the KL-6 and FGF-10 in groups of bulla site are higher than those in groups of bulla adjacent site and the results had statistically significant (P ＜ 0.05),while there was no statistically significant of MMP-9 in the two groups(P ＞0.05).Conclusion The expression of the KL-6 and FGF-10 in the bulla site in primary spontaneous pneumothorax patients was higher than that in the normal site ; the pulmonary fibrosis mediated by KL-6 and the lung-bronchial congenital abnormalities mediated by abnormal expression of FGF-10 might have correlation with bulla formation.There was no statistically significant of the MMP-9 expression between the two groups and the correlation between inflammation mediated by MMP-9 and bulla formation was not clear.
