The safety among acute ischemic stroke patients with asymptomatic intracranial aneurysm after the administration of intravenous thrombolysis
10.3760/cma.j.issn.1006-7876.2014.09.009
- VernacularTitle:无症状颅内动脉瘤的急性脑梗死患者静脉溶栓治疗安全性的系统评价
- Author:
Huping CHEN
;
Xianrong ZENG
;
Chun GAO
;
Yuanyuan CHENG
;
Sichang REN
;
Qin ZHAO
- Publication Type:Journal Article
- Keywords:
Intracranial aneurysm;
Brain infarction;
Thrombolytic therapy;
Meta-analysis
- From:
Chinese Journal of Neurology
2014;47(9):643-647
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the safety among acute ischemic stroke patients with asymptomatic intracranial aneurysm after the administration of intravenous thrombolysis.Methods We searched database including Wanfang,CNKI,VIP,Pubmed,EMBASE,EBSCO HOST and Metstr data for all the cohort studies on the use of thrombolysis for acute ischemic patients with asymptomatic intracranial aneurysm,and ascended the correlated references listed on the articles.Meta-analysis was conducted based on the methods recommended by the Cochrane collaboration.The outcomes of the meta-analysis were intracerebral hemorrhage (ICH),symptomatic intracerebral hemorrhage (sICH),subarachnoid hemorrhage (SAH).Results Four cohort studies included 707 patients,of whom 48 patients had asymptomatic cerebral aneurysms.The risk ratio prevalence of ICH among those patients did not differ statistically with those without aneurysms (RR =1.17,95％ CI 0.69-1.99,P =0.56).No statistical differences were found in both odds ratio prevalence of sICH (OR =1.70,95％ CI 0.44-6.59,P =0.45) and SAH (OR =1.13,95％ CI 0.20-6.27,P =0.89) between the patients with asymptomatic cerebral aneurysms and those without.Conclusion Current evidence did not indicate that the risk of hemorrhage increased in acute ischemic stroke patients with asymptomatic intracranial aneurysm after the administration of intravenous thrombolysis.
