Distribution characteristic of MTA 1 and its relationship with MMP-9,VEGF-C protein expression in human laryngocarcinoma
10.3969/j.issn.1671-8348.2014.26.004
- VernacularTitle:喉癌中 MTA1分布特点及其与 MMP-9、VEGF-C蛋白表达的相关性分析
- Author:
Chunbei HUANG
;
Guohua HU
;
Pujiang DONG
;
Yu GONG
- Publication Type:Journal Article
- Keywords:
laryngeal neoplasms;
metastasis associated 1;
vascular endothelial growth factor C;
matrix metalloproteinase 9
- From:
Chongqing Medicine
2014;(26):3418-3421
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression characteristic of metastasis associated 1(MTA1) protein in laryngocarcino-ma tissue and to analyze its relationship with matrix metalloproteinase-9(MMP-9) and vascular endothelial growth factor C(VEGF-C) proteinin .Methods The Western blot method was adopt to detect the expression levels of MTA1 ,MMP-9 and VEGF-C protein in the specimens of normal laryngeal mucosal tissue ,paracarcinoma tissue and tumor tissue from 40 cases of laryngocarcinoma .Re-sults Compared with the groups of laryngocarcinoma without lymph node metastasis ,paracarcinoma and normal tissue ,the expres-sion level of MTA1 protein in the laryngocarcinoma with lymph node metastasis group was significantly increased (P<0 .05) .The expression of MTA1 protein in the laryngocarcinoma tissue was significantly correlated with the lymph nodes metastasis ,tumor staging and differentiation degree of laryngocarcinoma (P<0 .05) and was positively correlated with the expression of VEGF-C and MMP-9 (P<0 .05) .Conclusion MTA1 may participate in the development ,progress and metastasis of laryngocarcinoma .Moreo-ver the regulating effect may exist among MTA1 ,MMP-9 and VEGF-C .
