Advances of immunologic dysregulation mechanism in biliary atresia
10.3760/cma.j.issn.2095-428X.2014.17.016
- VernacularTitle:胆道闭锁免疫失调机制的研究进展
- Author:
Jiang WANG
;
Shan ZHENG
- Publication Type:Journal Article
- Keywords:
Biliary atresia;
Mechanism;
Immune dysregulation
- From:
Chinese Journal of Applied Clinical Pediatrics
2014;29(17):1342-1345
- CountryChina
- Language:Chinese
-
Abstract:
Biliary atresia(BA) is a destructive inflammatory obliterative cholangiopathy of neonates affecting both intrahepatic and extrahepatic bile ducts.BA is more common in east Asia.Genetic susceptibility,viral infections,and immune dysregulation may be related to BA,but immune dysregulation may play a key hole in the pathogenesis of BA.A current view of the pathogenesis of BA is that it may involve both a primary perinatal hepatobiliary viral infection and a secondary generation of an autoimmune-mediated bile duct epithelial injury.The etiology of BA is unknown,but there is evidence for the involvement of immunologic dysregulation mechanisms,which will be discussed in this review.
