Reversible Posterior Leukoencephalopathy Syndrome.
10.3348/jkrs.2001.45.4.339
- Author:
Eun Ja LEE
1
;
Chang Joon SONG
;
Won Jong YU
;
Kook Jin AHN
;
So Lyung JUNG
;
Yeon Soo LEE
;
Ji Chang KIM
;
Soon Young SONG
;
Ja Hong KOO
;
Man Deuk KIM
;
Si Won KANG
Author Information
1. Department of Diagnostic Radiology, The Catholic University of Korea.
- Publication Type:Original Article
- Keywords:
Brain, MR;
Brain, diseases;
Brain, edema
- MeSH:
Basal Ganglia;
Brain;
Cerebellum;
Cyclosporine;
Eclampsia;
Edema;
Female;
Follow-Up Studies;
Frontal Lobe;
Gadolinium DTPA;
Headache;
Hematoma;
Humans;
Hypertension;
Infarction;
Magnetic Resonance Imaging;
Migraine with Aura;
Neurologic Manifestations;
Occipital Lobe;
Pons;
Posterior Leukoencephalopathy Syndrome*;
Pre-Eclampsia;
Pregnancy;
Prognosis;
Rabeprazole;
Renal Insufficiency;
Seizures;
Temporal Lobe;
Thalamus
- From:Journal of the Korean Radiological Society
2001;45(4):339-346
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To review reversible posterior leukoencephalopathy syndrome. MATERIALS AND METHODS: We reviewed 22 patients (M:F=3:19; age, 17-46 years) with the characteristic clinical and imaging features of reversible posterior leukoencephalopathy syndrome. All underwent brain MRI, and in three cases both CT and MRI were performed. In one, MRA was obtained, and in eleven, follow-up MR images were obtained. We evaluated the causes of this syndrome, its clinical manifestations, and MR findings including the locations of lesions, the presence or absence of contrast enhancement, and the changes seen at follow-up MRI. RESULTS: Of the 22 patients, 13 had eclampsia (six during pregnancy and seven during puerperium). Four were receiving immunosuppressive therapy (three, cyclosporine; one, FK 506). Four suffered renal failure and one had complicated migraine. The clinical manifestations included headache (n=12), visual disturbance (n=13), seizure (n=15), focal neurologic sign (n=3), and altered mental status (n=2). Fifteen patients had hypertension and the others normotension. MRI revealed that lesions were bilateral (n=20) or unilateral (n=2). In all patients the lesion was found in the cortical and subcortical areas of the parieto-occipital lobes; other locations were the basal ganglia (n=9), posterior temporal lobe (n=8), frontal lobe (n=5), cerebellum (n=5), pons (n=2), and thalamus (n=1). All lesions were of high signal intensity on T2-weighted images, and of iso to low intensity on T1-weighted images. One was combined with acute hematoma in the left basal ganglia. In eight of 11 patients who underwent postcontrast T1-weighted MRI, there was no definite enhancement; in one, enhancement was mild, and in two, patchy. CT studies showed low attenuation, and MRA revealed mild vasospasm. The symptoms of all patients improved. Follow-up MRI in nine of 11 patients depicted complete resolution of the lesions; in two, small infarctions remained but the extent of the lesions had decreased. CONCLUSION: Reversible posterior leukoencephalopathy syndrome develops in patients with toxemia of pregnancy, renal insufficiency or complicated migraine, and those who undergo immonosuppresive therapy. The characteristic MR finding is edema in cortical or subcortical areas of the parietal and occipital lobes, without enhancement after Gd-DTPA injection. Early recognition of this readily treatable condition may obviate the need for extensive, invasive investigations, and prompt treatment can lead to a favorable prognosis.
