Hollow periodic mesoporous organosilicas nanoparticles for efficient ultrasound-based imaging and ultrasound-mediated therapy
10.3760/cma.j.issn.1004-4477.2014.05.019
- VernacularTitle:载紫杉醇有机硅造影剂用于高效的超声影像、超声介导药物释放和超声介导的辅助肿瘤化疗
- Author:
Xiaoqin QIAN
;
Wenping WANG
;
Yu CHEN
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Neoadjuvant therapy;
Targeted therapy;
Paclitaxel;
Organosilicon compounds
- From:
Chinese Journal of Ultrasonography
2014;23(5):438-442
- CountryChina
- Language:Chinese
-
Abstract:
Objective To Study the application of ultrasound mediated drug-loading ultrasound contrast agents in auxiliary cancer chemotherapy.Methods Carrying paclitaxel (PTX) hollow periodic mesoporous organosilicas(HPMOs) were prepared by Structural differences selective etching method.The drug release kinetics of ultrasound mediated in vitro were evaluated at different time points of ultrasound radiation to PTX-HPMOs.The cell survival were evaluated by CCK8 experiment.Results ① The drug loading of PTX-HPMOs was 91 mg/g.②The achieved HMONs showed the high stability and excellent contrast enhancement for ultrasound imaging both in vitro.HPMOs showed the same good effect of contrastenhanced ultrasound imaging as SonoVue.③Drug-loaded HMONs exhibit ultrasound-responsive drug release performance.The ultrasonic stimulation can increase the release of 18 ％ of PTX each time.④ After ultrasonic stimulation,PTX-HPMOs showed good antitumor effect in vitro.Conclusions The new type of drug loading ultrasound contrast agents show good ultrasonic imaging and can help the cancer chemotherapy at the same time.
