Early diffusion tensor imaging findings in animal models of acute diffuse axonal injury
10.3760/cma.j.issn.1001-8050.2014.05.022
- VernacularTitle:急性弥漫性轴索损伤模型的建立与早期弥散张量成像表现
- Author:
Yongshan ZHU
;
Kunlin XIONG
;
Yulong ZHANG
;
Zhiyong YIN
- Publication Type:Journal Article
- Keywords:
Brain injuries;
Diffuse axonal injuries;
Diffusion tensor imaging;
Rabbits
- From:
Chinese Journal of Trauma
2014;30(5):460-463
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish animal models of diffuse axonal injury (DAI) and discuss the early functional MRI findings.Methods Twenty-five adult white rabbits were divided into control group (n =5),mild DAI group and severe DAI group (n =6) according to random number.Mild DAI group was subdivided into mild DAI 3 h (n =6),1 day (n =4) and 1 week (n =4) groups.Routine MRI and diffusion tensor imaging (DTI) were performed.Parameters measured were fractional anisotropy (FA),apparent diffusion coefficient (ADC),axial diffusivity (AD) and radical diffusivity (RD).Results Significantly increased FA (P＜0.01) and decreased ADC (P＜0.05) and RD (P＜0.01) were detected in severe DAI group compared to control group,but there was no significant variation in AD between the two groups (P ＞ 0.05).Each parameter remained almost unchanged in mild DAI 3 h group and mild DAI 1 week group,but FA was increased (P ＜ 0.01) and RD decreased (P ＜ 0.05) in mild DAI 1 day group,with no changes of ADC and AD.Conclusion DTI is a sensitive way to detect the occurrence and development of DAI and can provide referential images for early DAI diagnosis.
