White matter microstructure alterations in the patients with generalized anxiety disorder: a diffusion weighted imaging study
10.3760/cma.j.issn.1674-6554.2014.06.012
- VernacularTitle:广泛性焦虑障碍患者不同脑区白质结构磁共振弥散加权成像研究
- Author:
Junyan ZHANG
;
Jianan WANG
;
Bin XU
;
Jiayu GUO
;
Wei ZHANG
- Publication Type:Journal Article
- Keywords:
Diffusion weighted imaging;
Cingulate;
Generalized anxiety disorder;
Diffusion coefficient
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2014;23(6):517-518
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the white matter microstructure alternations in the patients with generalized anxiety disorder (GAD) with diffusion weighted imaging.Methods 19 patients with GAD and 20 matched healthy controls were assessed using apparent diffusion coefficient (ADC) and exponential apparent diffusion coefficient (eADC) in the regions of interests (ROIs) approach.The ROIs were the white matter of bilateral cingulate and bilateral hippocampus.Results Significantly increased ADC values were found in GAD patients (0.78±0.02,0.79±0.03) with respect to normal controls in the right and left anterior cingulate white matter.Significantly decreased eADC values were found in GAD patients (0.46±0.01,0.45±0.01) in the right and left anterior cingulate white matter.Conclusion Diffuse cingulate white matter alterations on DWI in GAD denote the disruption of white matter integrity.
