Association of sortilin-related receptor 1 gene single nucleotide polymorphisms with the risk of sporadic Alzheimer's disease
10.3760/cma.j.issn.1674-6554.2014.05.013
- VernacularTitle:分拣蛋白受体1基因单核苷酸多态性与散发性阿尔茨海默病相关性
- Author:
Chunhui JIN
;
Xiaowei LIU
;
Jianmin YUAN
;
Feng ZHANG
;
Jianzhong ZHU
;
Shui YU
;
Zaohuo CHENG
- Publication Type:Journal Article
- Keywords:
SORL1;
Alzheimer's disease;
Single nucleotide polymorphism
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2014;23(5):427-429
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between the sortilin-related receptor,L (DLR class) A repeats containing (SORL1) gene single nucleotide polymorphisms (SNPs) and sporadic Alzheimer's disease (SAD) in Han Chinese populations.Methods Five candicate SNPs,including rs985421,rs12364988,rs4598682,rs3781834,and rs3781836,within the SORL1 gene were genotyped by LDR-PCR methods,and the association of these SNPs with SAD risk were also analyzed in a case-control study with 179 SAD and 106 healthy controls.Results The results indicated that the A allele frequency of the SORL1 SNP rs985421 was significant difference between SAD and healthy controls (Trend test:P =0.0044,P adj =0.022; Allelic:P=0.0023,P adj =0.012).In subjects without APOE s4 allele,higher frequency of the A allele of rs985421 was observed in SAD patients compared with control subjects by the stratified analysis (OR=2.260,95％ CI =1.269-4.024,P=0.0048).In addition,logistic regression analysis further revealed that the A allele of SORL1 SNP rs985421 was significantly associated with SAD risk (OR=1.968,95％ CI =1.273-3.042,P=0.002).However,no positive signals in other four SNPs within the SORL1 gene were observed (all P＞ 0.05).Conclusions The A allele of SORL1 SNP rs985421 may be an APOE ε4-independent factor associated with SAD risk.
