Expression of glucose-regulated protein 78 in ovarian cancer tissues and its clinical significance
10.3760/cma.j.issn.1673-4904.2014.15.001
- VernacularTitle:葡萄糖调节蛋白78在卵巢癌组织中的表达及临床意义
- Author:
Liying ZHANG
;
Aili XU
;
Dandan YUAN
;
Limin AI
;
Peiling LI
- Publication Type:Journal Article
- Keywords:
Ovarian neoplasms;
Glucose-regulated protein
- From:
Chinese Journal of Postgraduates of Medicine
2014;37(15):1-3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of glucose-regulated protein (Grp) 78 in ovarian cancer tissues and its clinical significance.Methods The expression of Grp78 in 60 cases of ovarian cancer tissue,15 cases of ovarian borderline tumor tissue,10 cases of normal ovarian tissue,10 cases of ovarian cyst tissue,was detected by immunohistochemistry,and analyzed the relationship between its expression and clinicopathological features of ovarian cancer.Results The expression of Grp78 in ovarian borderline tumor and ovarian cancer tissue was significantly higher than that in normal ovarian and ovarian cyst tissue[7/15 and 68.3％ (41/60) vs.1/10 and 1/10] (P ＜0.05).The expression of Grp78 was positively correlated with clinicopathological staging and lymphatic metastasis of ovarian cancer (P ＜ 0.05),negatively correlated with histological differentiation (P ＜ 0.05).No correlation with age and ascites (P ＞ 0.05).Conclusions The levels of Grp78 are elevated in ovarian cancer specimens; high expression of Grp78 maybe participate in the occurrence,development,and prognosis of ovarian cancer.Increased expression of Grp78 might be a useful marker for predicting the carcinogenesis and progression of ovarian cancer.
