Effect of the etanercept on the hip pain in children with ankylosing spondylitis
10.3760/cma.j.issn.2095-428X.2014.12.016
- VernacularTitle:依那西普对强直性脊柱炎患儿髋关节疼痛的治疗作用
- Author:
Shuping WANG
;
Jing WANG
- Publication Type:Journal Article
- Keywords:
Etanercept;
Ankylosing spondylitis;
Hip joint;
Pain
- From:
Chinese Journal of Applied Clinical Pediatrics
2014;29(12):940-942
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the early effect of the etanercept on the hip pain in children with ankylosing spondylitis(AS).Methods Seventy-seven patients were randomly divided into etanercept group (group A,n =21 cases),diclofenac sodium group (group B,n =20 cases),sulfasalazine plus methotrexate group (group C,n =19 cases),placebo control group (group D,n =17 cases).Group A was treated with etanercept 0.8 mg/kg,once a week.Group B was given diclofenac sodium enteric-coated tablets 1 mg/kg,2 times a day.Group C was treated with sulfasalazine tablets 15-25 mg/kg,2 times a day and methotrexate tablets 10-15 mg/m2,once a week.Group D patients were given vitamin C 0.395 g,2 times a day,then the effect of different drugs on AS hip pain in children was observed.Results One day after administration,the visual analogue scale (VAS) score of the etanereept group and diclofenac sodium group was significantly different statistically compared with the placebo control group,and this effect continued until more than 14 days.Sulfasalazine with methotrexate group had no difference in the experimental time window compared with that of the placebo control group.The VAS score of the etanercept group compared with the diclofenac sodium was significantly different statistically,and this effect continued until more in 14 days.Conclusion Etanereept can relieve the hip pain in children with AS rapidly and continuously.
