Recent advances in the treatment of Kawasaki disease
10.3760/cma.j.issn.2095-428X.2014.09.017
- VernacularTitle:川崎病治疗新进展
- Author:
Bo YANG
;
Jun LUO
;
Ying ZHANG
;
Zhaoyan ZHANG
- Publication Type:Journal Article
- Keywords:
Kawasaki disease;
Treatment;
Intravenous immunoglobulin
- From:
Chinese Journal of Applied Clinical Pediatrics
2014;29(9):707-709
- CountryChina
- Language:Chinese
-
Abstract:
Kawasaki disease (KD) is an acute systemic vasculitis that primarily affects young children aged from 6 months to 4 years.KD may lead to coronary artery abnormalities in 25％-30％ of the children.The timely use of high dose intravenous immunoglobulin (IVIG) can significantly reduce the incidence of coronary artery aneurysms.Most clinicians use IVIG combined with aspirin as conventional therapy.But how to deal with those IVIG-resistant patients is a dilemma.With the deepening of research,many researchers have found that some second-line or third-line drugs such as corticosteroids,tumor necrosis factor-α inhibitors,and calcineurin inhibitors work better,and can effectively reduce the complication rate.The recent advances of the treatment of KD were summarized in this paper.
