Research Progress in the mechanism of histone deacetylase inhibitors as radiosensitizers
10.3760/cma.j.issn.1673-422X.2014.06.008
- VernacularTitle:组蛋白去乙酰化酶抑制剂放疗增敏机制研究进展
- Author:
Kan WU
;
Zhibing WU
;
Xufeng CHENG
;
Shenglin MA
- Publication Type:Journal Article
- Keywords:
Histone deacetylases;
Protease inhibitors;
Radiation-sensitizing agents;
Neoplasms
- From:
Journal of International Oncology
2014;41(6):425-428
- CountryChina
- Language:Chinese
-
Abstract:
One leading research target of modern tumor radiotherapy is to increase radiosensitization of tumor and improve curative effect of radiotherapy.Histone deacetylase inhibitors are epigenetic drugs that can play a part in radiosensitization through means of induction of apoptosis,inhibition of repair of DNA doublestrand breaks,cell cycle arrest,improvement of tumor cell hypoxia and increase of reactive oxygen species.There is an urgent need to develop biomarkers based on these pathways,which can promote clinically individualized treatment.
