Regulation of stem cell cycle and pluripotency by CDK and Myc
10.3760/cma.j.issn.1673-4181.2014.03.015
- VernacularTitle:CDK及Myc等对干细胞周期和多能性的调控作用
- Author:
Yanwei WU
;
Lixing FAN
;
Jinjin ZHANG
;
Yanchao XING
- Publication Type:Journal Article
- Keywords:
Stem cells;
Cell cycle;
Cyclin-dependent kinase;
Myc;
Pluripotency
- From:
International Journal of Biomedical Engineering
2014;37(3):189-192
- CountryChina
- Language:Chinese
-
Abstract:
Stem cells have self-renewal and differentiation potential.Cyclin-dependent kinase (CDK) plays an important role in promoting pluripotency and self-renewal.The crucial activity of S-phase,DNA replication,presents a unique opportunity during the cell cycle for the genetic and epigenetic regulation that may be involved in stabilizing the pluripotent state.It is also clear that Myc acts to coordinate both the cell cycle and the pluripotency transcription network in stem cells.Here we review the regulating mechanisms of stem cell cycles and pluripotency by CDK and Myc to help researchers obtain a better understanding of mutual regulation of the cell cycle and the pluripotent state by CDK and Myc which may be exploited in regenerative medicine.
