Effects of microgravity on bone marrow mesenchymal stem cells into osteogenic differentiation
10.3760/cma.j.issn.1673-4181.2014.03.012
- VernacularTitle:微重力对骨髓间充质干细胞成骨分化的影响
- Author:
Xinchang ZHANG
;
Biao HAN
;
Qiangsong WANG
;
Hao LI
;
Xizheng ZHANG
- Publication Type:Journal Article
- Keywords:
Microgravity;
Bone marrow mesenchymal stem cells;
Osteogenic differentiation
- From:
International Journal of Biomedical Engineering
2014;37(3):175-178
- CountryChina
- Language:Chinese
-
Abstract:
Bone marrow mesenchymal stem cells (BMSCs) is a kind of multipotent adult stem cells,which is one of the most important seed sources of tissue engineering.Microgravity has inhibitory effects on osteogenic differentiation of BMSCs,which will cause bone mass reduction and changes of bone micro-structure that finally lead to osteoporosis.This process is regulated by multiple signaling pathways such as mitogen-activated protein kinase (MAPK) pathway,Notch pathway and Wnt/β-catenin pathway which co-regulated BMSCs osteogenic differentiation under microgravity.Studying the effects of microgravity on BMSCs into osteogenic differentiation can clarify the mechanism of bone loss,put forward new targets for the treatment of diseases and provide a useful reference for the development of China's space industry.
