Selection of the quality control ingredients based on absorption of multicomponent in Fructus Lycii

VernacularTitle:枸杞子质量控制成分遴选研究
Author: Yanli PAN ; Mingmin TANG ; Yang LIU ; Jiamei XIANG ; Jingjuan WANG ; Meiling ZHU ; Li WEI ; Wenning YANG
Publication Type:Journal Article
Keywords: Fructus Lycii; Everted rat gut sacs; Absorption of intestinal; Quality control ingredients
From: International Journal of Traditional Chinese Medicine 2014;(8):726-730
CountryChina
Language:Chinese
Abstract: Objective To select the components for quality control of Fructus Lycii based on the absorption of its extract. Methods To investigate metabolism of components of Fructus Lycii, everted rat gut sacs was carried out as well as the blood was taken from abdominal aorta,.and all samples were analysised by HPLC. Results There are twelve constituents absorbed between ileum and jejunum of rat , and four constituents were detected in the blood. Compound 2, 3, 4, 5, 6, 9, 10, 11 were absorbed in prototype forms in the intestine directly,and compound 1, 7, 8, 12 were new ones. On the other hand, four compositions(3, 7, 10, 13)could be absorbed into blood through analysis serum samples obtaining from aorta abdominalis of rats. Two of them (3, 10)could be absorbed directly by intestine, while(7)was absorbed into blood in new form . Conclusion Based on the intestinal absorption experiment and analysion of compsition in blood, components (3, 10, 13) can be the quality control ingredients of Fructus Lycii.