Behavioral differences in learning and memory abilities among three animal models of Alzheimer′s disease assessed by Morris water maze test
- VernacularTitle:3种拟痴呆动物模型在 Morris 水迷宫行为学测试中学习记忆行为的差异
- Author:
Bin LI
;
Shuling XIE
;
Liyan PENG
;
Fei WANG
;
Kun YANG
;
Wenbin WU
- Publication Type:Journal Article
- Keywords:
Model of Alzheimer′s disease;
Morris water maze test;
Behavioral difference;
Learning and memory abilities;
Rat;
Mouse
- From:
Journal of Medical Postgraduates
2014;(7):683-685
- CountryChina
- Language:Chinese
-
Abstract:
Objective The study was to evaluate the behavioral differences in learning and memory abilities among three ani -mal models of Alzheimer′s disease. Methods Three SD rat models(n=20) were used in this study.The first SD rat model was es-tablished by intracerebral injection of Aβ25-35 into the bilateral hippocampus , the second mouse model was induced by intraperitoneal in-jection of scopolamine and the third was a senescence accelerated mouse model .Morris Water maze test was performed to investigate behavioral differences by comparison to corresponding blank control groups ( sham operation group , blank group and P8 group ) . Results The learning and memory abilities of senescence accelerated rats and scopolamine -treated rats were worse than those of the corresponding control groups, especially the scopolamine-treated rat ([35.47 ±3.78]s vs [50.61 ±3.94]s, P<0.01).There was no significant difference between Aβrats and sham-operated rats(P>0.05). Conclusion The model of Alzheimer′s disease in-duced by intraperitoneal injection of scopolamine represents more distinct changes in learning and memory abilities .Morris water maze test can be used to well evaluate whether the scopolamine-induced model is successfully established or not .
