Influences of different anesthesia methods or adjuvant chemotherapy on hemorheological parameters in patients with cervical cancer
- VernacularTitle:宫颈癌患者术前辅助化疗和不同麻醉方法对血液流变学的影响
- Author:
Liyan KANG
;
Haidong WANG
;
Qingfeng HU
;
Hongming WANG
;
Weian XU
- Publication Type:Journal Article
- Keywords:
Cervical cancer;
Adjuvant chemotherapy;
General anesthesia;
Combined general epidural anesthesia;
Hemorheology
- From:
The Journal of Clinical Anesthesiology
2014;(7):669-671
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the influences of different anesthesia methods or adjuvant chemotherapy on hemorheological parameters in patients with cervical cancer.Methods Sixty pa-tients with cervical cancer were equally randomized into two groups.Patients in group A received three courses of chemotherapy preoperatively while those in group B did not.The patients of group A and B were divided respectively into two subgroups,combined epidural general anesthesia group (groups A1 and B1),general anesthesia group (group A2 and B2).Blood samples were taken for the hemorheological measurement at 5 min before induction of anesthesia,60 min after induction of anes-thesia and at the end of surgery.Results Red cell deformability index (EDI)was significantly lower in group A than that in group B;Erythrocyte rigidity index (ERI)and blood viscosity were higher in group A compared with those in group B (P <0.05).In groups A1 and B1,EDI,plasmic viscosity packed ERI,and ERI were all lower than those before anesthesia induction (P < 0.01 );while in groups A2 and B2 Hct decreased.Conclusion The patients of cervical cancer after chemotherapy showed some hemorheological changes characterized by a lowered EDI.Combined general and epidural anesthesia can significantly improve the above parameters.
