Effects of controlled hypotension with sevoflurane on hymodynamics and cerebral metabolic rate of oxy-gen in neurosurgery
- VernacularTitle:七氟醚控制性降压用于颅脑手术对围术期患者血流动力学和脑氧代谢的影响
- Author:
Jin LI
;
Degang ZHU
;
Xinmin FENG
;
Shuli ZHANG
- Publication Type:Journal Article
- Keywords:
Controlled hypotension;
Sevoflurane;
Hymodynamics;
Cerebral metabolic rate of oxygen
- From:
The Journal of Clinical Anesthesiology
2014;(7):672-675
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of controlled hypotension with sevoflurane on hymo-dynamics and cerebral metabolic rate of oxygen in neurosurgery.Methods Thirty-seven ASA Ⅰ or Ⅱpatients undergoing elective intracranial surgery were enrolled.The patients were treated with general anesthesia and assigned to two experimental groups,sevoflurane group (group S,n=20)and sodium nitroprusside group (group N,n=1 7).HR,BP,SpO2 and ECG were continuously monitored during operation.Blood samples were taken from radial artery and internal jugular bulb to determine cerebral arteriovenous oxygen differences (Da-jvO2 ) and cerebral metabolic rate of oxygen (CMRO2 ). Results The HR in group S were decreased during hypotension,5 min,10 min,20 min,and 30 min compared with group N (P <0.05).Da-jvO2 and CMRO2 both in two groups were decreased during hypotension(P < 0.05 ),but there was no difference between the two groups.RPP was lower in group S than in group N during hypotension.Conclusion Controlled hypotension with sevoflurane does not increase HR and improves cerebral blood flow-metabolism coupling.
