Clinical observation of whether pretreatment with a low dose of esmolol can reduce propofol injection pain
- VernacularTitle:小剂量艾司洛尔对丙泊酚注射痛的缓解作用
- Author:
Huifang JIANG
;
Jun FANG
;
Yanhong LIAN
- Publication Type:Journal Article
- Keywords:
Esmolol;
Propofol;
Injection pain
- From:
The Journal of Clinical Anesthesiology
2014;(7):676-678
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of esmolol pretreatment on propofol injection pain..Methods Ninety patients undergoing breast cancer surgery under general anesthesia were ran-domly assigned into three groups (n=30 each).Group E were pretreated with 5 mg/ml(total 2 ml)es-molol group L with 20 mg/ml (total 2 ml)lidocaine and group N with 2 ml normal saline.After one minute,each group was administrated propofol intravenouly.The pain and hemodynamic data were re-corded.Results Compared with group N,propofol injection pain degree decreased obviously in groups E and L (P <0.05).propofol injection pain occurred in 25 (83.3%)in group N,was signifi-cantly higher than that of 12 (40.0%)in group E and 14 (46.7%)in group L (P <0.05),propofol injection pain had no significant difference between groups E and L.Compared with T1 ,SBP,DBP decreased in groups E and L at T2 ,SBP decreased in group N at T2 significantly (P <0.05).Com-pared with T2 ,DBP was significantly higher at T3 in group E (P <0.05).Conclusion Pretreatment with low dose esmolol was effective in attenuating pain during propofol injection.
