Regulatory Effect of Xiaofeng Xuanqiao Decoction on IgE, IL-4, IFN-γ, Histamine in Guinea Pig with Allergic Rhinitis
- VernacularTitle:消风宣窍汤对变应性鼻炎豚鼠模型IgE、IL-4、IFN-γ、组胺的调控作用
- Author:
Xiaoyun WEI
;
Shouchuan WANG
- Publication Type:Journal Article
- Keywords:
al ergic rhinitis;
Xiaofeng Xuanqiao decoction;
IgE;
IL-4;
IFN-γ;
histamin
- From:
Journal of Zhejiang Chinese Medical University
2014;(7):881-884
- CountryChina
- Language:Chinese
-
Abstract:
Objective Discuss the treatment mechanism of Xiaofeng Xuanqiao Decoction on guinea pig with al ergic rhinitis. [Methods]Sixty guinea pigs were randomized into 6 groups: normal control group, al ergic rhinitis(AR) group, high-dosage, equivalent-dosage, low-dosage Xiaofeng Xuanqiao decoction group, and loratadine group. AR guinea pig model was successful y established by ovalbumin(OVA) chal enge method. Xiaofeng Xuanqiao decoction and loratadine were applied to intervene AR guinea pig. The serum levels of IgE and IL-4, IFN-γ, histamine were determined by ELISA methods. [Results]The expression levels of IgE and IL-4, histamine significantly increased,meanwhile the level of IFN-γsignificantly lower compared with the normal group(P<0.01). Compared with that in AR model group, the serum level of IgE and IL-4, histamine in high-dosage Xiaofeng Xuanqiao decoction group significantly decreased,but the level of IFN-γ increased(P<0.01); the levels of IgE and IL-4, histamine decreased in other medication groups, meanwhile the level of IFN-γ increased compared with the model group(P<0.05).[Conclusion]Xiaofeng Xuanqiao can promote the produce of IFN-γ, inhibit the formation of IL-4, promote the secretion of Th1/Th2 cytokines to restore balance, to relieve eosinophil activation, reduce the synthet-ic of IgE, reduce the release of histamine, in many ways to prevent al ergic rhinitis inflammation, to achieve therapeutic effect.
