Relationship and Research Prospects of T Helper Cells and Aplastic Anemia
- VernacularTitle:辅助性T细胞与再生障碍性贫血的关系及研究展望
- Author:
Yingying SHEN
;
Shengyun LIN
- Publication Type:Journal Article
- Keywords:
aplastic anemia;
Th1 cells;
Th2 cells;
Thl7 cells;
T fol icular helper cells;
Th9 ceus;
Th22 cells
- From:
Journal of Zhejiang Chinese Medical University
2014;(7):922-926
- CountryChina
- Language:Chinese
-
Abstract:
Objective To review the pathogenesis and research prospects in AA.[Methods] In this paper, we summarize the imbalance mechanism of Th1/Th2, and the relationship of fol icular helper T cells(Tfh),Thl7, Th9 ,Th22 with aplastic anemia. [Results]The imbalance of Th1/Th2 cells leads to bone marrow failure. Immunosuppressive therapy can inhibit Th1 cell, restore the balance. The pathogenesis of Tfh, Thl7, Th9 and Th22 is closely correlated with AA. [Conclusion] AA pathogenesis is complex, CD4+cellsubsets is related to the occurrence and development of AA. Detect the levels of immune cells in the serum of patients is beneficial for diagnosis and treatment of AA.
