Relationship between postoperative cognitive dysfunction and the expression of α1-antichymotrypsin in plasma
- VernacularTitle:术后认知功能障碍与α1-抗糜蛋白酶表达的临床研究
- Author:
Liyan SHI
;
Jing XU
;
Yanjie WAN
;
Chuanqing ZHANG
;
Haijun CHEN
- Publication Type:Journal Article
- Keywords:
Postoperative cognitive dysfunction;
α1-antichymotrypsin;
Ulinastatin
- From:
The Journal of Clinical Anesthesiology
2014;(7):637-640
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the expression ofα1-antichymot-rypsin (α1-ACT)in plasma and postoperative cognitive dysfunction(POCD).Methods The cognitive function of 64 patients undergoing operation under general anesthesia was evaluated by a battery of cognitive assessment instruments(BCAI)and the levels ofα1-ACT were measured at the time 1 d pre-operatively and 7 d and 3 months postoperatively.The patients were randomly divided into two groups:30 patients in ulinastatin group (group U)were injected with 10 000 U/kg ulinastatin,which was dissolved in 100 ml saline,within 20 min at the time of 30 minutes before induction;while control group (group C)were injected with the same volume saline.Results There was no significant differ-ence between the expression of α1-antichymotrypsin in patients with POCD and in control patients at the time before operation.Compared with control patients,the levels of α1-ACT in patients with POCD at the time of 7 d and 3 months postoperation were significantly higher (P <0.05).The levels of α1-ACT at 7 d postoperation were significantly higher than that preoperatively in both groups (P <0.05).The incidence of POCD in group U were significantly lower than that in group C,at the time of 7 d and 3 months after surgery (P <0.05).Conclusion POCD is associated with high expression of plasma α1-ACT.
