Correlation between postoperative cognitive dysfunction and serum level of S100β and NSE in on-pump heart valve replacement
- VernacularTitle:血清 S100β及 NSE 含量与心肺转流心脏瓣膜置换术后早期认知功能障碍的相关性研究
- Author:
Zheng GUAN
;
Yongjian ZHANG
;
Guixia JING
;
Wei YUAN
;
Jingjie LIU
- Publication Type:Journal Article
- Keywords:
Postoperative cognitive dysfunction;
S100β;
Neuron specific enolase
- From:
The Journal of Clinical Anesthesiology
2014;(7):656-658
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between postoperative cognitive dysfunction (POCD)and serum level of S100βand NSE in patients undergoing on-pump heart valve replacement. Methods Ninety-eight patients underwent elective heart valve replacement were enrolled and divided into two groups:POCD group (group P)and none POCD group(group NP)by the result of neurocog-nitive testing with MMSE performed preoperatively and on the first postoperative day.Serum S-100βprotein and NSE were measured before operation(T0 ),at the end of operation(T1 ),24 h(T2 )and 48 h(T3 ) postoperatively.Results The incidence of POCD on the first postoperative day was 45 (45.9%).Compared with T0 ,the S100βincreased at T1 in both groups (P <0.05),NSE increased at T1 and T2 in both groups,and NSE increased in group NP at T3 (P <0.05).There was no signifi-cant difference of NSE between groups P and NP.The prolonged recovery time(OR = 1.222,P =0.004)and increased concentration of S100βat the end of operation(OR=1.85,P =0.009)were pre-dictors of POCD on the first postoperative day.Conclusion There was a higher incidence of POCD af-ter on-pump heart valve replacement surgery.The prolonged recovery time and increased concentra-tion of S100βat the end of operation might be predictors of POCD.
