The observation for the clinical effect of prophylactic low dose of escitalopram in patients with depressive symptoms and overall symptoms of Parkinson′s
10.3969/j.issn.1671-8348.2014.21.013
- VernacularTitle:预防性给予小剂量艾司西酞普兰对帕金森患者抑郁及整体症状疗效分析
- Author:
Jianghuan ZHENG
- Publication Type:Journal Article
- Keywords:
Parkinson disease;
depressive disorder;
antidepressive agents;
piribedil;
escitalopram
- From:
Chongqing Medicine
2014;(21):2725-2727
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect of prophylactic low dose of escitalopram in patients with depressive symp-toms and overall symptoms of Parkinson′s .Methods 40 patients were divided into single drug group used alone Piribedil and com-bined treatment group used Piribedil and escitalopram ,20 cases in each group .Hamilton depression scale (HAMD) ,Parkinson′s disease questionnaire composite score standard (UPDRS) and 39 Parkinson′s disease questionnaire score (PDQ-39) prior treatment were used to assess the changes of the patients′degree of depression and the Parkinson′s overall symptoms .Results Compared with prior treatment ,the HAMD score in single drug group after two weeks treatment had no significant difference (P> 0 .05) , while in combined treatment group ,the HAMD score decreased significantly (P<0 .05) .Compared with prior treatment ,both in single drug group and the combined treatment group ,the UPDRS scores and PDQ-39 rating decreased significantly (P<0 .05) ,but without significant difference between the two groups(P>0 .05) .After six weeks treatment ,Compared with prior treatment ,both in single drug group and combined treatment group ,the HAMD score ,UPDRS score and PDQ-39 score had significantly decreased (P<0 .05) ,but without significant differences between the two groups (P<0 .05) .Conclusion Prophylactic low dose of escitalo-pram may be early control of symptoms of Parkinson′s patients with mild depression .It can also be used to improve the overall symptoms of Parkinson′s patients ,which propose new ideas for the clinical treatment of Parkinson′s disease .