The significance of heparanase and CD 44v6 expressing in non-small cell lung cancer
10.3969/j.issn.1671-8348.2014.20.023
- VernacularTitle:肝素酶和CD44v6在非小细胞肺癌中的表达及意义
- Author:
Taibing DENG
;
Wanxiu HUANG
;
Fengming TANG
- Publication Type:Journal Article
- Keywords:
carcinoma,non-small-cell lung;
heparin lyase;
tumor metastasis;
CD44v6
- From:
Chongqing Medicine
2014;(20):2606-2608
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the CD44v6 and heparanase in non-small cell lung cancer (NSCLC ) and adjacent normal lung tissues ,and to study the correlation of these two molecular in non-small cell lung cancer invasion and metastasis .Methods The expressing of CD44v6 and heparanase in 117 patients with non-small cell lung cancer tissues and 62 adjacent normal lung tissue was detected by immunohistochemical staining .Results The expression of CD44v6 in NSCLC was 54 .7% (64/117) ,which was sig-nificantly higher than in adjacent tissues of 4 .8% (3/62)(P<0 .05);the expression of heparanase in NSCLC was 86 .3% (101/117) ,which was significantly higher than the normal adjacent tissues 17 .7% (11/62)(P<0 .01);CD44v6 expression in NSCLC ex-pression was positive correlated with heparanase .Conclusion CD44v6 and heparanase are associated with the invasion and metasta-sis of NSCLC ,combined detection of the expression of the two molecular maybe has a certain reference value in determine the prog-nosis of NSCLC .
