Study on expression and relationship between adrenomedullin and integrinαvβ3 in human osteosarcoma
10.3969/j.issn.1671-8348.2014.19.011
- VernacularTitle:人骨肉瘤中肾上腺髓质素和整合素αvβ3的表达及相关性研究
- Author:
Liqiang ZHI
;
Wei MA
;
Weihua WANG
;
Xiaoping WANG
- Publication Type:Journal Article
- Keywords:
adrenomedullin;
integrinαvβ3;
osteosarcoma
- From:
Chongqing Medicine
2014;(19):2428-2431
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression and relationship between adrenomedullin (ADM )and integrinαvβ3 in different pathological grades ,clinical stages and histologic subtypes of human osteosarcoma .Methods The expression positiverate ,intensity , the average optical density (ALD) of ADM and integrinαvβ3 in 30 osteosarcomacases was detected with immunohistochemical SABC technique and image analysis system .Each pathological section observed by two pathologists respectively in the case of unknown clinical and pathological information .At least five representative high field of vision counting 100 cells observed at random ,in this way the degree of tumor grade ,stage and cell staining were determined by two pathologist who unknown clinical and pathological data .Results The positive rate and intensity of ADM and integrinαvβ3 were significantly increased with the increase of osteosarco-ma stage(P<0 .05) and the difference was significant in each stage(P<0 .05) .The expression of ADM was positive correlated with the expression of integrinαvβ3 .Conclusion The expression of ADM and integrinαvβ3 in different clinicopathological grades osteosar-coma are positive associated with malignant degree of tumor ,which suggest that both of them play an important role in malignant biological behaviors of human osteosarcoma .
