The expression of collagen fibers,NCAM1 and RUNX1 in blood-supply myocardium of myocardial bridge
10.3969/j.issn.1671-8348.2014.19.016
- VernacularTitle:胶原纤维、NCAM1和RUNX1在心肌桥供血心肌的表达
- Author:
Renkuan TANG
- Publication Type:Journal Article
- Keywords:
myocardial bridging;
blood-supply myocardium;
collagen fibers;
NCAM1;
RUNX1
- From:
Chongqing Medicine
2014;(19):2443-2445
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the express of collagen fibers ,NCAM11 and RUNX1 in blood-supply myocardium of myo-cardial bridge(MB) .Methods The Massion′s staining were conducted to reveal the morphology of collagen fibers in blood-supply myocardium among MB without artherosclerosis(group A) ,MB with artherosclerosis(group B) ,coronary artery disease(group C) , and non-cardiogenic instantly death(group D) .The expression level of NCAM1 and RUNX1 were detected among four groups using immunohistochemistry(IHC) and Western bolt ,respectively .Results There were a lot of collagen fibers in myocardium interstitial substance and/or heart muscle necrosis between group B and C ,but not almost collagen fibers between group A and D .The expres-sion of NCAM1 was positive in group B ,and mainly expressed on the cytoplasm and membranes of cardiac myocytes by IHC .group C was similar to results in vicinal myocardium with myocardial scar .However ,there was quite lowness or negative expression of NCAM1 in group A and D .Significant difference was found between group B as well as C and group A as well as D (P<0 .05) .The expression level of RUNX1 in blood-supply myocardium was almost like to the results of NCAM 1 .Conclusion MB with arthero-sclerosis might be lead to chronic myocardial ischemia .
