The relation between endothelium-dependent vasodilator function and platelet L-arginine/nitric oxide pathway in patients with percutaneous coronary intervention
10.3969/j.issn.1671-8348.2014.20.001
- VernacularTitle:冠心病介入术患者血管内皮依赖性舒张功能与血小板L-精氨酸／一氧化氮通路的关系
- Author:
Huijuan WEN
;
Yaqin LI
;
Yuying CUI
;
Yuqiao LI
- Publication Type:Journal Article
- Keywords:
nitric oxide;
percutaneous coronary intervention;
vascular endothelium dependent diastolic function;
nitric oxide syn-thase;
L-arginine transport
- From:
Chongqing Medicine
2014;(20):2545-2547
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate alteration and cross link of the vascular endothelium dependent diastolic function (FMD) and platelet endogenous L-arginine/NOS/NO pathway before and after percutaneous coronary intervention (PCI) .Methods The study included two groups :normal control group(17 cases) and PCI group(20 cases) .FMD of brachial artery and NO production , NOS activity ,L-arginine transport in platelets were examined respectively before ,immediately ,24 h and 72 h after PCI and the rela-tionships between them would subsequently be analysed .Results The preoperative FMD ,content of NO2 - ,NOS activity and L-ar-ginine of PCI group significantly decreased than the normal control group (P<0 .01) ,and further decreased in the immediate post-operative(P<0 .01) .Gradually recovered 24 h after surgery ,72 h after surgery ,the FMD ,NO2 - ,L-arginine transport ,NOS activity restored to the preoperative level (P>0 .05) .The analysis showed the obvious positive correlation between FMD and content of NO2 - or NOS activity ,or L-arginine transport of platelet ,respectively(P<0 .01) .Conclusion The pathway of platelet L-arginine/NOS/NO was significantly positively correlated with FMD and the detection of platelet L-arginine/NOS/NO can reflect the changes of vascular endothelial function with PCI .
