The impact to blood lipid in patients with HIV/AIDS using two different HAART regimens

VernacularTitle:两种 HAART 方案对 HIV／AIDS患者血脂的影响
Author: Hong LI ; Yuanyuan CHEN ; Yun HE ; Chaofeng LI ; Chunli LIU ; Yan SUN ; Qingxia ZHAO
Publication Type:Journal Article
Keywords: antiretroviral therapy,highly active; acquired immunodeficiency syndrome; HIV; lipids
From: Chongqing Medicine 2014;(20):2574-2576
CountryChina
Language:Chinese
Abstract: Objective To understand the impact to blood lipid in patients with HIV/AIDS using different HAART regimens . Methods According to HAART regimens ,102 HIV/AIDS patients were divided into two groups :D4T group(D4T+3TC+NVP) and AZT group(AZT+3TC+ NVP) .Blood lipids(TG ,TC ,LDL-C and HDL-C)at baseline ,24 weeks and 48 weeks after HAART were detected .Results Compared with paired t test ,TG ,TC and LDL-C at 24 weeks follow-up of the patients in D4T group were significantly higher than at baseline(P<0 .05) ,and TC at 48 weeks follow-up were still higher than at baseline(P<0 .05) .TG and TC at 24 weeks follow-up of patients in AZT group were significantly higher than at baseline(P<0 .05) .There were no significant difference at blood lipid between the two groups(P>0 .05) .Conclusion There are dyslipidemia of the patients with HIV/AIDS u-sing D4T-based and AZT-based regimens ,and the dyslipidemia are increase of TC and TG ,these increase is border higher .TG and TC at 24 weeks follow-up of the HIV/AIDS patients using D4T-based regimen are increased early ,and TC are still at higher level .